Critical Facts you should know about prescribing EPA/DHA PUFA dietary supplements…

1 Omega-3 fats originating from fish species are normally in triglyceride (TG) form. Ethyl esters (EE) are an alternative form of fats that are synthetically derived by reacting free fatty acids with ethanol (alcohol). The vast majority of fish oil concentrates sold globally, including those sold in North America are EEs. ¹

2 Two recent studies have assessed the absorption and bioavailability of ethyle ester (EE) versus triglyceride (TG) fish oils. The overall evidence suggests that TG fish oils are better absorbed in comparison to EEs. TG fish oil results in 50% more plasma EPA and DHA afer absorption in comparison to EE oils.² TG forms of EPA and DHA were shown to be 25% better absorbed than EE forms. ³

3 The Omega-3 fatty acids contained in Animi-3 are present in Triglyceride form for increased stability and improved bioavailability. ^2,3

**Footnotes

1. Segura R. (1988). Preparation of fatty acid methyl esters by direct transesterification of lipids with aluminum chloride-methanol. J Chromatogr.;441:99-113.
2. J Dyerberg, P Madsen, JM Moller, I Aardestrup, EB Schmidt. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leutkot. Essent. Fatty Acids 83 (2010), 137-141.
3. J Neubronner, JP Schuchardt, G Kressel, M Merkel, C von Schacky and A Hahn. Enhanced increase of omega-3 index in response to long term n-3 fatty acid supplementation from triacyglycerides versus ethyl esters. Eur. J. of Clin. Nutr. (2010), 1-8.
Animi-3 is indicated for nutritional supplementation only and is not FDA approved for treatment of disease.